Cardiac Troponins and Renal Failure

Cardiac troponins and renal failure: the evolution of a clinical test.

In this issue of Circulation, Khan and colleagues present the results of an elegantly performed meta-analysis of the prognostic implications of elevated levels of troponin T and I among asymptomatic patients with end-stage renal disease.1 After systematically collating the results of 28 cohort studies involving 3931 patients, they noted that an elevated troponin T level identified a group of en...

Cardiac troponins in renal insufficiency: review and clinical implications.

Patients with renal insufficiency may have increased serum troponins even in the absence of clinically suspected acute myocardial ischemia. While cardiovascular disease is the most common cause of death in patients with renal failure, we are just beginning to understand the clinical meaning of serum troponin elevations. Serum troponin T is increased more frequently than troponin I in patients w...

Cardiac troponins.

Cardiac troponins

Objective: To review the use of cardiac troponins as biomarkers for myocardial injury in human and veterinary medicine. Data sources: Data sources included scientific reviews and original research publications. Human data synthesis: Cardiac troponins have been extensively studied in human medicine. Finding an elevated cardiac troponin level carries important diagnostic and prognostic informatio...

[Prognostic value of circulatory cardiac troponins in heart failure].

Circulating cardiac troponins (cTn), the proteins that regulate actin and myosin interaction during muscle contraction, are detectable in patients without typical symptoms of acute coronary syndromes. The interpretation for their elevation in this context is challenging to the physician and to the scientist. The clinical potential of measuring the release of myofibrillar cTn into the bloodstrea...